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Protein Production & Developability Scientist

Nabla Bio

Nabla Bio

Cambridge, MA, USA
Posted on Thursday, May 16, 2024

Send a CV and why you're interested in working with us to hiring@nabla.bio.

About

Our mission is to generate new therapeutic opportunities by advancing AI and experimental technologies for drug design. Using AI and massively parallel experimentation, we design antibodies that precisely bind the disease target at the right location, while minimizing manufacturability and toxicity risks. We are a well-funded, revenue-generating, bilingual company of wet- and dry-lab scientists, and are founded by AI and protein design experts from Harvard University.

The role

Fueled by partnerships and increasing demand for internal R&D, we will be looking to you to help scale our antibody expression, purification, and developability measurement pipeline and apply it toward solving hard antibody design problems. This will include:

  • Developing high-throughput HEK and CHO-based antibody expression and purification
  • Prioritizing top development candidates by characterizing antibodies for key biophysical traits, including but not limited to, affinity, cross-reactivity, stability, polyspecificity, aggregation, and hydrophobicity
  • Working together with our dry-lab and other wet-lab scientists to establish a rapid and seamless production and testing pipeline for characterizing machine learning generated antibody designs

Qualifications

  • Bachelor’s or master’s degree, with 3+ years of antibody production and characterization experience in industry
  • Proficiency in molecular biology and cloning of full-length antibodies and antibody fragments into mammalian expression vectors
  • Extensive experience in HEK and CHO-based antibody expression at a variety of throughputs, including up to 96-well expression
  • Experience with HEK and CHO-based antibody production at a variety of volumes, from mL to L scale.
  • Proficient in standard antibody purification approaches, with a track record of being able to adapt these protocols or develop new ones for challenging antibodies
  • Extensive experience in performing developability assessments on purified antibody. Includes experience with assays such as DSF, SMAC, BLI/SPR, HIC, ELISA, among other standard biophysical characterization techniques.
  • Well-organized, and would enjoy establishing an operationally efficient antibody production and characterization pipeline that works reliably
  • Problem-focused, and interested in working in a high-intensity, fast-paced environment often driven by deadlines
  • Value unblocking colleagues before yourself, and are excited to mentor/train junior colleagues